Following topical application Minoxidil is poorly absorbed from normal intact skin, with an average of approximately 1.7% of the total applied dose ultimately reaching the systemic circulation. Minoxidil works in part by partially enlarging the hair follicles and reversing the miniaturization process. By enlarging miniaturized follicles, the growth phase of the hair cycle is prolonged, allowing the hair to become longer and thicker looking. Minoxidil also causes vasodilation of the microcirculation around the hair follicles which may stimulate hair growth. Following cessation of topical dosing of Minoxidil, approximately 95% of systemically absorbed Minoxidil is eliminated within four days. Minoxidil does not cross the blood brain barrier and are excreted principally in the urine.
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